Cell chambers are commonly used in cell experiments, such like: co-culture experiments, chemotaxis experiments, cell migration experiments, cell invasion, and drug delivery. Among them, permeable supports can effectively improve the culture of polar cells as they allow cells to secrete and absorb molecules from their basal and apical surfaces, thereby metabolizing in a more natural way, simulating the in vivo environment to the greatest extent. To cultivate some special cell lines.
Polycarbonate membranes have high pore density, allow more exchange through the membrane, and have excellent cell adhesion properties, making them ideal for transport studies and other applications that require optimal cell growth.
Polycarbonate membranes are also well suited for barrier analysis. Compared with other membranes, it has a higher, more sustained and more stable transepithelial resistance value over a longer period of time.
Features:
* Available membrane pore size 0.4um、3um、5um、8um
* Sterilized,RNase/DNase free, Pyrogen free, Cytotoxin free
*PC membrane: low adsorption rate, reducing the loss of small molecular proteins and other compounds
*PC membrane is not easy to tear or curl and it is easy to operate when taking out the cell.
*Compatible with most solvents used for fixation and staining
Application：
*Tumor migration and invasion assays
*Epithelial and endothelial cell barrier assays
*Dermis/Epidermal and Epithelial Tissue Models
*Chemotactic effect research
*Co-culture research:cell-cell interaction,cell-mother cell interaction,cell-substrate interaction
Choosing Guide:
| Application | Cell | Recommended membrane pore size |
| ADME (compound transport and penetration across the enterocyte barrier) | Caco-2、MDCK | 0.4 μm |
| Co-culture and cell differentiation, cell imaging | Primary cells, tumor stem cells | 0.4 μm、1.0 μm |
| Macromolecular or viral transport, secretion | 1.0 μm、3.0 μm | |
| Cell migration and invasion (angiogenesis), cell chemotaxis (migration), or endothelial migration Axonal proliferation, co-culture | Endothelial cells, leukocytes Neurons | 3.0 μm |
| cell migration and invasion | lymphocytes, macrophages | 3.0 μm、5.0 μm |
| Tumor cell migration and invasion Blood cell chemotaxis or transendothelial cell migration, co-culture | Tumor-derived cells, leukocytes, tumor stem cells, MSCs | 8.0 μm |
